Shana Bergman (TECBio 2015) published a paper titled, “Modeling global changes induced by local perturbations to the HIV-1 capsid”, with her research with Dr. Tim Lezon (Assistant Professor, Comp & Sys Bio, Drug Discovery Institute). The research highlights:
• Coarse-grained modeling of mutation and binding in HIV-1 capsid.
• Dynamics are robust against simulated linking of capsomers within hexamers.
• Inter-hexamer linking stabilizes most mobile regions of capsid.